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GLP-1 family and metabolic compounds studied for weight and glucose research.
8 results
Retatrutide is a first-in-class triple hormone receptor agonist targeting glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon receptors simultaneously. With a molecular formula of C221H342N46O68, molecular weight of 4731.4 g/mol, and CAS number 2381089-83-2, it represents a novel approach to metabolic research. Research has demonstrated that retatrutide’s triple agonism produces distinct metabolic effects beyond what dual agonists achieve. The glucagon receptor component increases energy expenditure through hepatic lipid oxidation and thermogenesis, while GIP and GLP-1 receptor activation provides complementary effects on insulin secretion, appetite regulation, and gastric motility. Phase 2 clinical data showed unprecedented weight reduction compared to existing peptide therapies. Preclinical studies reveal retatrutide significantly reduces hepatic triglyceride content and improves markers of non-alcoholic steatohepatitis (NASH). The glucagon component drives hepatic fat mobilization and amino acid catabolism, while the incretin components maintain glycemic control despite glucagon-mediated hepatic glucose output. This balance makes it a compound of significant research interest in metabolic disease models. Each vial contains 16mg of lyophilized retatrutide at greater than 99.9% purity, verified by independent HPLC and mass spectrometry. Supplied as a sterile lyophilized powder.
$160.99· ships same-day
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a mitochondria-derived peptide consisting of 16 amino acids with the sequence MRWQEMGYIFYPRKLR. It has a molecular weight of 2174.6 g/mol and CAS number 1627580-64-6. MOTS-c is encoded within the mitochondrial 12S rRNA gene and represents a class of signaling molecules known as mitochondrial-derived peptides (MDPs). Research has established MOTS-c as a key regulator of metabolic homeostasis. Studies demonstrate it activates AMPK (AMP-activated protein kinase), the master cellular energy sensor, and modulates the folate-methionine cycle through inhibition of the de novo purine biosynthesis pathway. This leads to accumulation of AICAR, an endogenous AMPK activator, creating a metabolic signaling cascade that influences glucose uptake, fatty acid oxidation, and mitochondrial biogenesis. In preclinical models, MOTS-c administration has been studied in models of age-dependent and high-fat diet-induced insulin resistance, physical performance capacity in aged mice, and cellular stress response pathways. Studies also reveal its translocation to the nucleus under metabolic stress, where it regulates gene expression through interaction with antioxidant response elements (ARE). Research into MOTS-c’s role in aging has demonstrated declining endogenous levels with age across multiple tissues, correlating with metabolic dysfunction. Supplementation studies in aged mice show restoration of insulin sensitivity and improvement in physical performance metrics. Each vial contains 40mg of lyophilized MOTS-c at greater than 99% purity, verified by third-party HPLC and mass spectrometry analysis.
$141.99· ships same-day
